The invention relates to an aromatic essential oil spray and application thereof in preparation of a special paper handkerchief. The aromatic essential oil spray comprises the following compositions in percentage by weight according to the formula: 1) 5% of cassia twig essential oil; 2) 5% of fresh ginger essential oil; 3) 3% of Fructus Xanthii essential oil; 4) 2% of radix Angelicae Dahuricae essential oil; 5) 5% of benzyl alcohol; and 6) the balance of absolute ethyl alcohol. The aromatic essential oil spray has the functions of sweating, removing internal heat and relieving stuffy noses, and is mainly applied in the preparation of the special paper handkerchief applicable to patients with initial cold. The paper handkerchief has obvious efficacy on relieving symptoms such as aversion to cold, fever, rhinobyon, running nose and sneezing occurring in the initial stage of cold by virtue of fragrance activity on patients in use. The invention further relates to the paper handkerchief comprising the aromatic essential oil spray.