The application discloses an industrial production method and device for a highly isotactic polybutylene alloy. The production method comprises the following steps: firstly polymerizing propylene in a prepolymerization kettle at -20 to 90 DEG C to form polypropylene particles loaded with active centers, carrying out reduced pressure recovery on the unreacted propylene monomer into a propylene monomer gas cabinet, putting polypropylene loaded with active centers and 1-butene monomer into the polymerization kettle and polymerizing at -10 to 80 DEG C to obtain a granular polybutene alloy, removing partial unreacted monomer under reduced pressure, feeding the materials in the prepolymerization kettle into a flash kettle to further remove unreacted 1-butene, sequentially introducing nitrogen into the flash kettle for replacing air, discharging the granular isotactic polybutene alloy from a discharge valve arranged at the bottom of the kettle, extruding and packaging. The production device comprises a batching system, a polymerization system, a post-treatment packaging system, a vacuum nitrogen system, a degassing flash system and a utility system. By the method and the device, the industrialized synthesis of the polybutylene alloy can be achieved and the method has the advantages of no organic solvent and no waste emissions and belongs to the scope of environment-friendly clean production.