The invention discloses a method for blocking a severely polluted deep well sandstone reservoir and belongs to the technical field of oil field blocking. For the severely polluted deep well sandstone reservoir to be blocked, pollution of the immediate wellbore vicinity of the sandstone reservoir is removed firstly; then cement squeezing blocking is carried out on the well section with pollution removed through a packer cement squeezing method; the pollution of the immediate wellbore vicinity of the sandstone reservoir is removed through small acidification; high energy composite perforation is carried out on the sandstone reservoir, and the pollution of the immediate wellbore vicinity of the sandstone reservoir is removed. The method breaks through a conventional blocking thought, pollution of the sandstone reservoir to be blocked is removed firstly, permeability of the reservoir is improved, and then the reservoir is blocked. The blocking success rate is improved, and the period of blocking validity is prolonged. A reference is provided for similar well blocking construction in future.