Spur cancellation systems and related methods are disclosed for radio frequency (RF) receivers and other implementations. Disclosed embodiments effectively remove spurs caused by digital clock signals or other spur sources by determining which spurs will fall within a channel selected to be tuned, utilizing a spur cancellation module to generate a cancellation signal, and subtracting this cancellation signal from the digital information. The cancellation signal can be initially generated with a known frequency and estimated values for unknown spur parameters, such as amplitude and phase. Digital feedback signals are then used to adjust the spur parameters. If the spur frequency is not known precisely, digital feedback signals can also be used to adjust the frequency of the cancellation signal. Where multiple receive paths are provided within a multi-receiver system, multiple spur cancellation modules can be used to remove spurs generated by digital clocks within each of the receive paths.