The invention provides a high-strength high-permeability chemical sand prevention agent, and a preparation method and an application thereof. The high-strength high-permeability chemical sand prevention agent is composed of a proppant, a cementing agent, an accelerator, a curing agent and a coupling agent according to a certain ratio. The preparation method comprises the following steps: above raw materials are mixed at a specific temperature, and are stirred, and the obtained mixture is cured for a certain period of time to obtain the high curing strength sand prevention agent. The sand prevention agent has good tolerance to acid, water, salt and oil, has high stability in high temperature and high humidity environment, and is mainly used in chemical sand prevention well extract production, serious casing deformation well sand prevention, and sand prevention of wells without mechanical sand prevention and oil water wells with low reservoir temperature in order to increase liquid production of the oil well, prolong the period of validity of well sand prevention, increase the amount of oil and reduce the production cost.