The invention relates to a follow-up sealing device of a shaft. The follow-up sealing device is especially applicable to motive sealing of the shaft, and includes a sealing box 1, a sealing gasket base 2, a sealing gasket 3, a moving shaft 4, sealing fillers 5, a pressing sleeve 6, a pressing cover 7, etc. The follow-up sealing device of shaft has the advantages that as the sealing fillers are elastic and in the shape of particles or strips and are mixed with lubricants, they will trace the center of the shaft in a follow-up mode under pressure of the pressing sleeve, and further leakage caused by moving shaft eccentricity or vibration abrasion can be avoided. The sealing fillers contain lubricants so the friction resistance of the moving shaft is reduced. After abrasion of the sealing fillers, new sealing fillers can be added, so waste of the sealing materials is avoided.