The invention discloses an insulin pump with a dynamic closed-loop control in the field of medical equipment. The insulin pump comprises an administration mechanism, a driving mechanism, a detection mechanism and a dynamic control module, wherein the administration mechanism is connected with the insulin pump and transmits insulin injection amount information; the driving mechanism is connected with an injection unit of the insulin pump, and transmits and controls the injection amount information; the detection mechanism is connected with a glucometer and transmits human body blood glucose information; and the dynamic control module is connected with the driving mechanism of the insulin pump and transmits insulin-blood glucose level control information. The insulin pump with the dynamic closed-loop control can effectively reduce the unstabilizing factors due to a complex blood glucose system and has the relatively nice robustness after simulation testing. The insulin pump can control the blood glucose level of the diabetics and the injection amount of the insulin in time through model prediction and iterative control, so that the blood glucose level of the diabetics tends to be stable; and therefore, the effect of the insulin pump to control the injection automatically is achieved.