Provided packaged orthodontic assemblies and methods compressively retain an orthodontic appliance in a container along opposing sides of the appliance adjacent the bonding surfaces of its base. This can be done using a mechanism that limits contact between the appliance and the container while accommodating a substantial range of transverse base dimensions. This engagement mechanism allows an adhesive-coated appliance to be retained in a consistent orientation for convenient dispensing, while limiting potentially adverse interactions between the adhesive and the container. By avoiding loss of the adhesive components during storage, these assemblies and methods can extend shelf life and provide consistent adhesive handling properties.