The invention relates to a traditional Chinese medicine composition for treating children infectious mononucleosis. The traditional Chinese medicine composition comprises carapax trionycis, raw oyster shells, herba schizonepetae, isatidis radix, mint, folium isatidis, radix glycyrrhizae, herba violae, lycium bark, scrophulariae, shikonin, olibanum, gypsum rubrum, concha arcae, radix scutellaria and indigo naturalis, and has the effects of clearing away heat and toxic materials. After the traditional Chinese medicine composition is taken, the medicine treats both symptoms and root causes from the whole human body, has the functions of nourishing the liver and kidney, calming the liver, recovering lymph glands and expelling toxin and achieving detoxication, eliminates EB viruses fundamentally, promotes blood circulation and the respiratory cycle, and enables the blood circulation system and the respiratory system to recover self-adjusting functions; completely relieves the symptoms of strength lack, fever, myalgia, lymphadenopathy, liver gland swelling and the like, improves microcirculation, adjusts endocrine function disorder, and finally achieves the purpose of curing the children infectious mononucleosis.