The invention provides a method of interference rejection and information transmission in a heterogeneous network. The method comprises the steps of installing an adjusting period Tc with a preset first time length, and cutting the adjusting period into a plurality of time fragments with equal time lengths; installing each time fragment in the adjusting period to either an information transmission period Ton or an information channel monitoring period Toff randomly by nodes in the system; monitoring by the nodes in the system in a shared channel occupied by all Toffs in the existing adjusting period; adjusting the time ratio of the Ton to the Toff in a next adjusting period according to the occupation condition of the shared channel monitored when the existing adjusting period is completed, and taking the next adjusting period as an existing adjusting period. According to the method provided by the invention, the shared channel resources can be more uniformly distributed, and the performance of an LTE/LTE-A (Long Term Evolution /Long Term Evolution-Advanced) system can be improved when the LTE/LTE-A system and other systems coexist.