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发明公开
CN104710425A 一种替格瑞洛新结晶及其制备方法 有权 转让

一种替格瑞洛新结晶及其制备方法
摘要：
本发明公开了一种替格瑞洛的新结晶及其制备方法。本发明的替格瑞洛新结晶的粉末X-射线衍射在2θ为5.7±0.2°处有最强峰，粒径d(0.9)小于30μm。本发明的替格瑞洛结晶质量稳定，晶型稳定，粒径小且分布均匀，为制剂制备节省了工序，降低了生产成本，更适合于作为原料药使用；制备方法所使用溶剂价廉易得且毒性小、更适合规模化生产。
摘要（英）：

The present invention discloses a ticagrelor new crystal and a preparation method thereof. The ticagrelor new crystal powder X-ray diffraction shows a strongest peak at 2 theta for 5.7 +/-0.2 degree, and teh particle size d (0.9) is less than 30 mum. The ticagrelor new crystal is stable in quality, stable in crystal form, small particle size and uniform in distribution, the preparation procedure is saved, the production cost is reduced, and the ticagrelor new crystal is more suitable for use as a raw material medicine; a solvent used in the preparation method is cheap, easy to get, and less in toxicity, and is more suitable for large scale production.

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