The invention discloses an antifreeze sheathing and shielding cable for aerospace use. The cable is composed of ten groups of tin-plated nickel conductor cable cores, eight groups of zinc-plated nickel conductor cable cores, eight groups of silver-plated nickel conductor cable cores and six outer protecting layers, wherein the six outer protecting layers include the polytetrafluoroethylene propylene insulating layer, the silver-plated steel strip armor layer, the silver-plated aluminum strip armor layer, the chlorosulfonated polyethylene protective sleeve layer, the tin-plated aluminum wire shielding layer and the silver-plated annealed copper strip armor polyethylene protective sleeve layer from inside to outside in sequence. The cable has the advantages of being resistant to freezing, good in shielding effect, good in drainage effect, and capable of being widely used in the fields including aerospace, ships and petrochemical engineering.