The invention discloses a surgical ligaturing instrument and relates to the technical field of medical instruments. The surgical ligaturing instrument comprises an operation handle (1), a disposable inner core (2), a ligature line control handle (3), a knotting control handle (4), a ligature line attachment point (5), a control line attachment point (6) and a ligature loop (7), wherein the operation handle (1) is arranged at one end of the disposable inner core (2), the ligature loop (7) is arranged at the other end of the disposable inner core (2), and the ligature line control handle (3) and the knotting control handle (4) are arranged on the operation handle (1) and are connected with the ligature line attachment point (5) and the control line attachment point (6) on the disposable inner core (2) respectively. The surgical ligaturing instrument has the advantages of reasonable structural design, simplicity in operation, convenience in use, safety, reliability, small foreign matter size, controllability in ligaturing force, less proneness to ligation falling or tissue cutting and capability of meeting use requirements of medical workers.