The invention relates to the technology of circuit line loss monitoring, in particular to a circuit line loss comprehensive monitoring device and solves the problems that in the prior art, data are acquired incompletely and labor cost is excessively high. The device comprises a CPU main control chip, an analog input module, a digital input module, a frequency input module, a data storage module, an Ethernet communication module, a GPRS communication module, a wired communication module, a monitoring platform computer, a three-phase electric energy metering chip, a CT current acquisition module, a PT voltage acquisition module and a touch screen. The CPU main control chip, the analog input module, the digital input module, the frequency input module, the data storage module, an Ethernet communication module, the GPRS communication module, the wired communication module are integrated in one circuit board; the CPU main control chip adopts a Linux operation system. The device is adaptive to circuit line loss monitoring.