The invention relates to a sole and provides an anti-slide shoe sole and a shoe with the shoe sole. The anti-slide shoe sole has the anti-slide performance in both processes of standing contact and force-applied walking, and people also can stably walk even if a slippery ground. The anti-slide sole comprises an outsole, wherein the outsole corresponding to a heel, an arch, metatarsal bones, and a toe of the sole is respectively composed of a heel zone, an arch zone, a metatarsal bones zone and a toe zone; a square bulge zone is arranged on the heel zone of the outsole, and the square bulge zone is formed by several square bulges, a draining grove for draining fluid is arranged between adjacent square bulges; a cylindrical bulge zone is arranged on the metatarsal bones zone, and composed of several cylindrical bulges; a draining gap for draining fluid forms between adjacent cylindrical bulges; a strip-shaped bulge zone is arranged on the toe zone of the outsole and formed by a plurality of strip-shaped bulges, and a draining groove for draining fluid is formed between adjacent strip-shaped bulges.