The invention relates to the field of medicines, particularly relates to applications of 1-benzyl-4-(2,4-dichloro phenethylamino)piperidine or pharmaceutically acceptable salts or pharmaceutically acceptable carriers thereof in preparation of medicines used for preventing or treating diseases related to NEDD8 kinase abnormity, and more particularly relates to applications of the 1-benzyl-4-(2,4-dichloro phenethylamino)piperidine in preparation of antitumor medicines. Pharmacological results show that: the compound has good NEDD8 inhibiting activity, good tumor cell proliferation resistance, a good function of promoting tumor cell apoptosis and good in-vivo antitumor activity, and can be used for prepare medicines treating tumor clinically.