The invention provides aminoquinazoline derivatives, or their stereoisomers, geometric isomers, tautomers, despinners, nitrogen oxides, hydrates, solvates, metabolites, metabolism precursors and pharmaceutically acceptable salts or prodrugs. The above compounds can be used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the above compounds and a use of the above compounds or their pharmaceutical composition in preparation of drugs for treating proliferative diseases.