The invention provides an optimization method for a multi-power-source operation mode. The optimization method for the multi-power-source operation mode comprises the following steps that time sequence thermal load in an electric heat supply area is converted into time sequence electrical load and added into system time sequence electrical load, and a total continuous electrical load curve is made; the continuous thermal load curve of the total time sequence thermal load of remained areas except for the electric heat supply area is made; a wind electricity quantity generation absorption capacity optimization model of electricity/thermal comprehensive energy supply is established; an optimization model with a smallest system coal consumption cost as a goal is established, and the system total coal consumption cost under different electric heat supply scale is calculated; an optimization model with a smallest unit heating fee as a goal is established, and the heating fee total cost of the electric heat supply area under different electric heat supply scales is calculated; comprehensive analysis evaluation is performed on the calculated results of the three above optimization modes, and the most economical operation mode is chosen.