The invention discloses a safety injection integrated system. The safety injection integrated system comprises a safety injection system and an advanced safety injection box, wherein the advanced safety injection box is arranged in a safety shell, is communicated with a pressure vessel and is used for filling the pressure vessel with cooling agent; and the safety injection system penetrates through the safety shell in a sealing manner, and two ends of the safety injection system are communicated with the pressure vessel and a reloading water tank outside the safety shell respectively for injecting the cooling agent in the reloading water tank into the pressure vessel. According to the safety injection integrated system, the safety injection flow rate required by accident analysis can be met through cooperation of the safety injection system and the advanced safety injection box; the quantity of equipment is reduced greatly and the system structure is simplified due to the integrated system formed by a single safety injection pump and a single advanced safety injection box through cooperation, the maintaining and repairing difficulty of the system and the parts is greatly lowered, the expenses of equipment purchasing, equipment installation, equipment operation, equipment maintenance and the like are reduced, and the building cost and the operation and maintenance costs of a nuclear power plant are reduced accordingly.