The invention belongs to the field of pharmaceutical preparation, and in particular, relates to a parecoxib sodium freeze-dried powder injection containing sodium chloride and a preparation method thereof. The parecoxib sodium freeze-dried powder injection for injection has the advantages of uniform color and luster, smooth surface, no dusting and wall sticking phenomena, no collapse and no crimping, has the most significant effects in good stability, re-dissolution after being placed for a long period of time and quite little valdecoxib conversion amount, and ensures the product injection safety.