The invention provides a display panel, a drive method of the display panel, a pixel drive circuit and a display device, and relates to the field of display techniques, so that the problems that drive signals, which achieve dot inversion, of an existing display panel are high in change frequency and large in power consumption are solved. The pixel drive circuit comprises a drive signal generation module and a drive signal interface module, wherein the drive signal generation module outputs at least one group of first drive signals and second drive signals, a first drive signal receiving end receives the first drive signals, and a second drive signal receiving end receives the second drive signals; one output end of the drive signal interface module is connected with second ends of two switch units; the first switch unit is used for outputting the first drive signals input from the first end of the first switch unit out of the second end of the first switch unit under the control of a first clock signal; the second drive signal is used for outputting the second drive signals input from the first end of the second switch unit out of the second end of the second switch unit under the control of a second clock signal.