The invention discloses a traditional Chinese medicine preparation for treating diffuse systemic scleroderma. The traditional Chinese medicine preparation selects the following raw material medicines by weight: 20-30 g of astragalus membranaceus, 10-20 g of Chinese yam, 10-20 g of angelica sinensis, 10-20 g of pericarpium citri reticulatae, 10-20 g of agilawood, 10-20 g of tangerine, 10-20 g of curcuma zedoary, 10-20 g of radix linderae, 10-20 g of fructus liquidambaris, 8-15 g of cassia twig, 8-12 g of Chinese honeylocust spine, 8-12 g of pangolin scales, 8-12 g of sargent gloryvine, 8-12 g of rhizoma pinelliae, 8-12 g of asarum and 8-12 g of monkshood. The traditional Chinese medicine preparation has the main function of tonifying and benefiting qi in spleens and lungs and the auxiliary functions of promoting blood circulation to remove blood stasis, and warming meridians and expelling cold, a human body is abundant in vital qi, blood circulation is smoothed, defensive qi and nutrient blood are filled and reconciled, skin viscera is warmed, moistened and nourished, yin and yang are interactive, and both the qi and the blood are abundant and active; therefore, the efficacies of benefiting qi and removing blood stasis, softening hard mass and eliminating rheumatism are achieved.