The invention provides a disaster tolerance processing method and device, a main data center and a backup data center. The disaster tolerance processing method comprises the steps that a second logic unit number, sent by the backup data center, of a second storage subregion is obtained through a channel between a first storage region network and a second storage region network; a first logic unit number and a second logic unit number of a predetermined first storage subregion are added into storage configuration of a first virtual machine; according to the storage configuration, an operation system for file systems corresponding to the first storage subregion and the second storage subregion is established on the first virtual machine; data of a first application are synchronously written into the first storage subregion and the second storage subregion through independent disk redundancy RAID of the operation system. By means of the disaster tolerance processing method and device, the main data center and the backup data center, it can be ensured that the data can be synchronously written into the main data center and the backup data center in real time, and the zero loss of the data is ensured under the situation of a disaster of the main data center.