The invention discloses a traditional Chinese medicine and western medicine combined medication contraindication early-warning system. A method includes information inquiry about single traditional Chinese medicine and western medicine and contraindication inquiry about mutual relations between multiple traditional Chinese medicine and western medicine. Data sources mainly include ancient literature of eighteen incompatible herb and mutual antagonism nineteen herb medicine pairs, experimental data, Chinese patent medicine data, modern literature and molecule data. According to collection of the modern literature, through an HTTP request, literature containing related bad contraindication keywords on web pages is captured, and an expert checks collection data so that useful modern literature data can be stored into a local database in the same format and real-time updating of the data inside the database can be ensured.