The invention relates to an optimized operation method of a pumped-storage power station and wind power combined system and belongs to the field of optimized operation of power systems. The method includes: building an optimized operation model of the pumped-storage power station and wind power combined system based on a unit combination, which uses lowest grid generation cost as a target function, constraint conditions of power balance constraint, spinning reserve constraint, climbing ability constraint, unit characteristic constraint and pumped-storage power station constraint, and boundary conditions of a daily load curve, grid loss and power parameters; solving the model to obtain an operation scheduling command to allow optimized operation of the combined system. Wind power intermittence, volatility and prediction inaccuracy are fully considered, and the spinning reverse constraint is corrected to optimize the operation of the combined system; by the use of the method, evident benefits are brought to the pumped-storage power station, in terms of hump modulation and trough stuffing, wind power fluctuation balancing, wind curtailment reduction and system coal consumption reduction.