The invention discloses a wine box offset printing process. Anhydrous offset plate positive image type PS plate is used in the printing process, and patterns printed by means of the plate edition are stereo and clear. Grains are established in a structure layer of the plate edition, so that the specific surface area of the PS plate is improved, and the hydrophilic performance of the plate is improved. Paper is subjected to humidity regulation processing before the paper is arranged so that the attachment environment of ink can be improved, and the ink can be tightly adhered to the surface of the paper. Used plate wetting liquid is ethanol, the ethanol serves as the plate wetting liquid and is low in price, the surface tension of the ethanol is large, and water usage amount for layout spreading is easily decreased. In addition, the ethanol volatilizes to carry away moisture in the plate wetting liquid and printing heat. Wet-type overprint is adopted, and the overprint mode enables the ink to be combined tightly during overprinting.