The invention provides a method for preparing a speckle pattern including heterogeneous deformation based on numerical calculation. The method comprises the following steps of acquiring strain of each unit and displacement of each node by utilizing a non-classical numerical calculation technology; building a correlation between a certain area of a unit or a surrounding node in a numerical model and a sub area in a digital image related method; mapping the position and grey value of each pixel in the sub area before deformation to a deformed sub area. The essence of the method disclosed by the invention lies in that a result of the non-classical numerical value calculation technology is taken as the result of the digital image related method so that the un-deformed speckle pattern can be mapped on a deformed grid. The method disclosed by the invention can implement all steps by utilizing computer programming and can be used for making speckle pattern including heterogeneous deformation or localized deformation at high precision and high efficiency without being limited by the type of load. The speckle pattern made by the method disclosed by the invention is mainly applied to the field of scientific researches, such as inspection on calculation precision of the digital image related method under the condition of heterogeneous deformation or even localized deformation.