A multipurpose wire connection device includes a base plate, a conductive plate, a wire fixation screw, a fireproof box, a support, and a dustpan-shaped housing. The support is disposed on the base plate. The fireproof box includes a rear panel, a bottom panel, two side panels, and an inserted plate. The wire fixation screw is mounted on the conductive plate. The housing is fixed on the bottom plate by a housing fixing screw. The multipurpose wire connection device prevents sparking and red burning of a ground screw when lightning current passes therein, due to corroded contact in long-term exposure to wind and rain. It avoids fire and explosion accidents. It avoids screw corrosion and facilitates ground resistance measurement. The multipurpose wire connection device can also be used for electrical relay, division, and branching. It prevents fire, explosion, rain intrusion, and rust development. It is easy to disassemble.