The invention discloses an external fixation device needle threading fixture capable of being adjusted in multiple directions and at multiple angles. The external fixation device needle threading fixture comprises an up-down slide rod, an up-down slide block, a left-right slide rod and a kirschner wire clamping device. The up-down slide rod is a cuboid slide rod with the square cross section. A through threaded hole is formed in the up-down slide rod and is fixed to an external fixation frame through an adjusting and locking bolt. The up-down slide rod is sleeved with the up-down slide block. Two through holes which are orthorhombic in the horizontal air direction are formed in the up-down slide block. The left-right slide rod penetrates through one through hole. A left-right slide rod adjusting and fixing bolt and an up-down slide block adjusting and locking bolt are arranged at the two ends of the other through hole respectively. Adjustment of a stepless position and any angle is achieved, fine adjustment can be conducted, hole site blind areas which are vertically immobilized in the external fixation frame are successfully eliminated, the subsequent problem that a kirschner wire is not parallel to an up-down fixed ring is solved, and the four-freedom-degree adjustment and fixation of the kirschner wire can be achieved.