The invention discloses a cable reel loading and unloading rollover prevention device. The device comprises a pedestal, wherein a vertical plate is fixedly arranged on the upper side of the front end of the pedestal; supporting plates which extend forwards are arranged on the two sides of the front end of the pedestal; the vertical plate is provided with a lifting frame in a sliding manner; the bottom end of the lifting frame is provided with a pair of tray rollers extending forwards; the pedestal is also provided with a lifting drive device; the lifting drive device is connected with the lifting frame; the bottoms of the pedestal and the supporting plate are provided with rollers in a rotating manner respectively. During loading and unloading work of a cable reel, the cable reel can be effectively prevented from rolling, so that the phenomena of cable damage and operator injury are avoided, and the cable reels are tidily arranged and are convenient to use.