A high-elastic antibacterial non-woven fabric with a honeycomb structure comprises a plurality of compound fiber meshes sequentially stacked in a back-and-forth Z shape. Antibacterial agents are sprayed into the compound fiber meshes, the compound fiber meshes are sequentially in end-to-end connection, and hot melting fiber is clamped between the adjacent compound fiber meshes. When the high-elastic antibacterial non-woven fabric is manufactured, through preparation prior to mesh formation and a process of mesh formation through mechanical combing, an upper layer fiber mesh, an elastic fiber mesh and a lower layer fiber mesh are prepared respectively and then are overlaid into the compound fiber meshes through a fiber mesh compounding process; the upper layer fiber mesh and the lower layer fiber mesh are mixture of low melting point polyester short fiber and three-dimensional curly hollow polyester short fiber, and the elastic fiber mesh is mixture of low melting point polyester short fiber and elastic polyester short fiber. After the antibacterial agents are sprayed into the compound fiber meshes, the meshes are vertically laid through a vertical mesh laying process, the hot melting fiber is scattered between the compound fiber meshes, and then the high-elastic antibacterial non-woven fabric with the honeycomb structure is obtained through a drying, trimming and winding process.