A universal drop-out fusion tube structure includes a fusion tube, a base structure mounted at the bottom of the fusion tube and a top structure mounted at the upper end of the fusion tube. The base structure includes a base sleeve which sleeves the bottom of the fusion tube, a groove interface on one side of the base sleeve is connected with a base hanging head with a transverse supporting rod, a built-in spring and a spring pressing plate by means of a fixed hinge pin, and left and right ends of the transverse supporting rod are each equipped with at least two conducting rings. The top structure mainly comprises an operation ring ferrule, an upper moving contact ferrule and a top sleeve head which sleeve the upper end of the fusion tube in sequence, and a wedge-shaped contact body and a bar-shaped contact body are connected on the upper moving contact ferrule. The universal drop-out fusion tube structure has the characteristics of having a reasonable and compact structure, being convenient to use and install, having good reliability, being suitable for being matched with various fuses for use, reducing reserves of spares for emergency maintenance, and reducing the duration of emergency maintenance of a power failure.