The invention discloses streptomyces with heterodera glycines poisonous activity and application of the streptomyces, and relates to streptomyces and application of the streptomyces. The streptomyces with the heterodera glycines poisonous activity has the advantages that heterodera glycines can be prevented and treated by microorganisms, the streptomyces is low in prevention and treatment cost and free of hazards to human, livestock and environments and is environmental friendly; high and stable yields of soybeans can be guaranteed by the aid of original continuous cropping of high-yield soybean varieties; the streptomyces is streptomyces microflavus HKS1408 and is preserved in the common microorganism center of the China committee for culture collection of microorganisms, and the preservation number is CGMCC NO.10714; the streptomyces with the heterodera glycines poisonous activity can be used for preventing and treating the heterodera glycines.