The invention discloses a pipeline targeted descaling method. The pipeline targeted descaling method comprises following steps: S1, the position of a segment with dirt is calculated based on a pipeline inlet pressure break point when a positioning spherical pig runs in a pipeline; S2, the segments before and after the segment with dirt are provided with a soft spherical pig respectively for isolation, the two ends of the segment with dirt are blocked so as to form a descaling area, and a descaling agent is delivered to fixed points of the descaling area so as to form a descaling system, wherein the descaling agent comprises a solid retarded acid, a corrosion inhibitor, a penetrant, and a complexing agent; S6, after standing of 0.5 to 1h, full contact and dissolving of the descaling agent with accumulated dirt are realized; and S7, the descaling agent and the soft spherical pigs are removed. According to the pipeline targeted descaling method, the segment with dirt is isolated from the rest segments, qualified and fixed point delivering of the scaling agent can be realized, descaling of the segment with dirt can be carried out with pertinency, a result that the whole pipeline is full of the descaling agent is avoided, damage caused by the descaling process on the pipeline is reduced, high efficiency using of the descaling agent is realized, and operation cost is reduced greatly.