The present invention discloses an oxide inert anode making and application method, and relates to the non-ferrous metal metallurgy technology. The inert anode is based on RuO2 (ruthenium dioxide), and a dense high strength block is prepared by compounding the ruthenium dioxide with one or more materials such as an oxide, a metal, perovskite structure and the like, pressing and molding, keeping at a certain temperature in air atmosphere, and sintering for a certain time. The dense high strength block is used as an anode for electrolytic extraction of metals and alloys and the like in alkali metal or alkaline earth metal chloride molten salt electrolyte, the beneficial effects are that: the prepared anode is good in corrosion resistance, high in conductivity, easy in processing, and is an anode applicable to the green electrochemical metallurgy.