The invention relates to an injectable hydrogel preparation method, particularly relates to a preparation method for imitation chondrocyte epimatrix injectable hydrogel and belongs to the technical field of biomedical material preparation. According to the method, the ultraviolet light polymerization technology is used, methacrylic acylation silk fibroin and maleylation chitosan serve as the raw materials, and the imitation chondrocyte epimatrix injectable hydrogel is prepared. The hydrogel is composed of chondrocyte epimatrix injectable hydrogel imitation main ingredient of collagen and glycosaminoglycan all natural polymers and can simulate the microenvironment of chondrocyte epimatrix, and accordingly, adhesion, growth and multiplication of chondrocyte are promoted apparently, and the biocompatibility is good. Besides, the ultraviolet light polymerization technology is used, methacrylic acylation silk fibroin is used as main cross-linking points to be embedded in the maleylation chitosan to form a nanoparticle covalent cross-linked chitosan molecular chain nano enhanced hydrogel structure, and accordingly, the hydrogel is endowed with high mechanical strength, and the defect of low strength of the hydrogel is overcome completely.