The invention provides a cleaning device of a spherical camera. The problem that the outside of the spherical camera is inconvenient to clean is solved. The cleaning device of the spherical camera comprises a shell, a wiping assembly, a rotary driving assembly, a lifting driving assembly and a rotary plate, wherein the rotary plate is rotatably arranged in an inner cavity of the shell; the rotary driving assembly for driving the rotary plate to rotate is arranged above the rotary plate; the wiping assembly is arranged below the rotary plate; the lifting driving assembly which drives the wiping assembly to be close to the rotary plate or be far away from the rotary plate is arranged between the wiping assembly and the rotary plate; the wiping assembly comprises a support, a first cleaning brush and a second cleaning brush; the support is fixed on the lifting driving assembly; a first cleaning brush and a second cleaning brush are hinged to the bottom of the support; and cleaning erasers are respectively arranged at an acting end of the first cleaning brush and an acting end of the second cleaning brush. By the cleaning device of the spherical camera, the circumstance that the spherical camera is wiped manually is avoided, a monitoring effect on electrical equipment and lines is guaranteed, and dangers of workers who climb to a high position to clean the camera are avoided.