Provided is a comprehensive automatic measurement and control defect-eliminating guidance system. The system comprises a database used for storing spare part information, equipment account information, equipment defect information, and corresponding defect-eliminating guidance; a correlation account query module used for checking the equipment account information; a spare part query module used for checking the spare part information; and a defect management module, the defect management module comprises a defect input module and a defect query module, the defect input module is used for inputting the equipment defect information, the equipment defect information comprises device classification, fault classification, defect grade, and defect phenomenon, and the defect query module is used for comparing the database according to the inputted equipment defect information and obtaining the defect-eliminating guidance corresponding to the defect information. According to the system, the time for defect elimination of the comprehensive automatic system and the time occupied by defect processing are effectively reduced, and the operation is simple and standard.