The invention relates to the field of food processing and health medicine production, and in particular relates to a preparation method of compound Chuzhou chrysanthemum total flavonoid dropping pills. The preparation method comprises the following steps: firstly drying and crushing Chuzhou chrysanthemum, performing refluxing extraction by using an ethanol solution, and concentrating to obtain a Chuzhou chrysanthemum total flavonoid extracting solution; and then purifying the Chuzhou chrysanthemum total flavonoid extracting solution by virtue of D101 macroporous resin, weighing Chuzhou chrysanthemum total flavonoid purified liquid and a matrix after purification, uniformly mixing and finely grinding, adding absolute ethanol, heating and melting, completely volatilizing ethanol in a water bath to obtain a medicine extracting solution, adding borneol into the medicine extracting solution, also heating and melting, finally taking liquid paraffin as cooling liquid, and dropping to obtain the dropping pills by using a pill dropping machine. The compound Chuzhou chrysanthemum total flavonoid dropping pills disclosed by the invention can comply with the function of a conventional traditional Chinese medicine namely Chuzhou chrysanthemum total flavonoids on the improvement of myocardial ischemia of the heart, and can be used for improving myocardial damages caused by oxygen deficiency of the heart to a certain extent; and by adopting the compound Chuzhou chrysanthemum total flavonoid dropping pills, the absorption rate of medicines can be improved in medicinal cure effects, the penetration rate of the medicines can also be improved when the medicines are subjected to sublingual administration, and harms caused by acute angina pectoris diseases can be relieved.