The invention discloses a microchannel plate heat exchanger with sine-shaped flow channels. The microchannel plate heat exchanger comprises channel plates, division plates, clamping plates, hot fluid inlet and outlet ports, cold fluid inlet and outlet ports and fluid collecting hole channels, wherein the division plates are arranged on two sides of each channel plate, the channel plates and the division plates are alternately stacked and pressed to form cold and hot fluid heat exchange channels, and the sine-shaped flow channels are formed in the channel plates in the direction of opposite angles of the channel plates; fluid distribution channels are formed in the division plates, the cold and hot fluid heat exchange channels are communicated with the fluid distribution channels, and the fluid collecting hole channels are formed in four corners of each channel plate; the clamping plates are arranged outside the channel plates and the division plates, and the hot fluid inlet and outlet ports and the cold fluid inlet and outlet ports are formed in the clamping plates. With the adoption of the sine-shaped flow channels, the microchannel plate heat exchanger has the characteristics of light weight, compact structure, large heat transfer area in unit volume, small fluid pressure drop, self-cleaning function, long service life and the like and the heat exchange efficiency is improved.