A liquid charging and tablet filling machine belongs to the technical field of pharmaceutical manufacturing machinery and comprises a motor reducing gear, a vacuum system, a rack, a turntable and a transmission device, as well as a distribution device, a capsule separating device, a detection device, a liquid charging device, a tablet filling device, a rejecting device, a gluing device, a squeezer, a finished-product conveying device and a die cleaner which are sequentially arranged on the rack on the circumference of the turntable, wherein the distribution device, the capsule separating device, the tablet filling device, the rejecting device, the squeezer and the finished-product conveying device are all connected with the transmission device; the transmission device is connected with the motor reducing gear; the vacuum system is connected with the capsule separating device; the detection device is located between the distribution device and the liquid charging device; and when the turntable rotates to the corresponding work stations, charging and filling are finished correspondingly. The liquid charging and tablet filling machine can realize liquid charging and tablet filling of hard capsules; and as the inner walls of capsule caps are glued to realize internal sealing of the capsules, the process and the cost are reduced, and the capsules are easier to be absorbed by the human body.