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发明授权
CN104894244B 长链非编码RNA AFAP1-AS1的引物、检测试剂及其应用 有权

长链非编码RNA AFAP1-AS1的引物、检测试剂及其应用
摘要：
本发明公开了一种长链非编码RNA AFAP1‑AS1的引物、检测试剂及其应用，即用于制备鼻咽癌患者的辅助诊断和预后制剂，特别是制备出实时荧光定量分析法预测鼻咽癌患者预后的试剂盒。通过研究证实AFAP1‑AS1在鼻咽癌组织中表达上调，高表达AFAP1‑AS1的鼻咽癌患者比低表达AFAP1‑AS1的鼻咽癌患者预后差，因此，将AFAP1‑AS1的表达用于鼻咽癌患者的预后预测，可以为鼻咽癌患者的预后提供强有力的分子生物学依据，具有深远的临床意义和重要的推广应用前景。
摘要（英）：

The invention discloses a primer, detection reagent and application of a long-chain non-coded RNA AFAP1-AS1. The primer and the detection reagent of the long-chain non-coded RNA AFAP1-AS1 are used for preparing an auxiliary diagnosis and prognosis preparations for nasopharynx cancer patients and particularly used for preparing a kit for predicting prognosis of the nasopharynx cancer patients through a real-time fluorescence quantitative analysis method. It is proved through study that the expression of the AFAP1-AS1 in nasopharynx cancer tissue is increased, and the prognosis of the nasopharynx cancer patients with high-expression AFAP1-AS1 is poor than that of the nasopharynx cancer patient with low-expression AFAP1-AS1; in this way, by utilizing the expression of the AFAP1-AS1 for predicting the prognosis of the nasopharynx cancer patients, a powerful molecular biological foundation can be provided for the prognosis of the nasopharynx cancer patients, and the profound clinical significance and important application and popularization prospects are achieved.

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