The invention provides a heterogeneous multi-core SoC design evaluation system. The system comprises an assembly abstract modeling module for performing abstract modeling for a master-slave assembly of a bus, a design space definition module for setting each variable and the value range corresponding to each variable according to the SoC design demand, a performance index evaluation module for forming a first SoC structure according to each variable and the value range as well as performing simulation evaluation and comprehensive evaluation of the first SoC structure so as to obtain performance indexes of the SoC, a model training and exploring module for performing model training by the machine learning algorithm according to the performance index and each variable so as to obtain a predication module or a classifying module, and a system structural optimizing module for selecting a second SoC structure through the predication module or the classifying module, wherein the master-slave assembly comprises a coprocessor. With the adoption of the system, the design and evaluation of a heterogeneous multi-core SoC system structure can be assisted to be done.