Disclosed in the invention is a waterproof distribution box comprising a box body including a lower ventilation box body and an upper sealing box body. A ventilation box door and a sealing box door are respectively arranged at opening sides of the lower ventilation box body and the upper sealing box body. The sealing box door includes an inner side door and an outer side glass door. First sealing strips are arranged between the inner side door, the outer side glass door and the door frame of the upper sealing box body. A water blocking structure is arranged at the top of the upper sealing box body and contains a water blocking body; at least one horizontal drainage slot is formed in the water blocking body; and a first water blocking plate and a second water blocking plate are arranged at the front end and the rear end of the water blocking body obliquely. Besides, an air inlet fan and an exhaust fan are respectively arranged at the left side wall and the right side wall of the lower ventilation box body. According to the waterproof distribution box, the rainproof and waterproof performances are good; the insulation strength inside the distribution box can be maintained and the short-circuit phenomenon in the distribution box is prevented; the safety factor is high; and the service life of the box is prolonged.