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发明授权
CN104906590B 含巴西蜡的沃尼妙林注射液 有权 转让

含巴西蜡的沃尼妙林注射液
摘要：
本发明是一种外观为乳胶状的含巴西蜡的沃尼妙林注射液，在每升注射液中包含盐酸沃尼妙林150‑180g、巴西蜡2.5‑11g、体积比为4.5比3比3.3比1的三乙酸甘油酯/苯甲酸苄酯/1，2‑丙二醇/乙醇加至1升。在每升注射液中还包含单油酸甘油酯100‑150ml。在制备以上所述的每升注射液时，还可加入2水柠檬酸钠(C6H5Na3O7·2H2O)13.0‑31.2g，或加入10水碳酸钠(Na2CO3·10H2O)19.0‑31.9g。加入的柠檬酸钠或碳酸钠会与盐酸沃尼妙林发生反应，由此所制备的每升注射液中包含沃尼妙林碱和沃尼妙林酸式盐(盐酸盐或柠檬酸盐)150‑180g，巴西蜡2.5‑11g，单油酸甘油酯100‑150ml，体积比为4.5比3比3.3比1的三乙酸甘油酯/苯甲酸苄酯/1，2‑丙二醇/乙醇加至1升。
摘要（英）：

The invention relates to a carnauba wax-containing valnemulin injection with latex-like appearance. Each liter of the injection comprises 150-180g of valnemulin hydrochloride, 2.5-11g of carnauba wax, and the balance of glyceryl triacetate/benzyl benzoate/1,2-propylene glycol/ethanol with a volume ratio of 4.5:3:3.3:1. Each of the injection also comprises 100-150ml of glyceryl monooleate. In the preparation process of 1L of the injection, 13.0-31.2g of sodium citrate dihydrate (C6H5Na3O7.2H2O) or 19.0-31.9g of sodium carbonate decahydrate (Na2CO3.10H2O) is added. Added sodium citrate or sodium carbonate reacts with valnemulin hydrochloride. Each liter of the injection prepared in the invention includes 150-180g of valnemulin alkali and valnemulin acid salt (hydrochloride or citrate), 2.5-11g of carnauba wax, 100-150ml of glyceryl monooleate, and the balance of glyceryl triacetate/benzyl benzoate/1,2-propylene glycol/ethanol with a volume ratio of 4.5:3:3.3:1.

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