The invention discloses a process for manufacturing slope ecological restoration vegetation substrates, and belongs to the field of slope greening technologies. The process includes selecting sludge with the water content of 30%-50% and extracting solid contents in cow manure; mixing 7-9 parts of the sludge and 1-3 parts of extracts of the cow manure with one another to obtain mixtures; adding 0.1-0.4 kilogram of composite strain powder into each ton of the mixtures and sufficiently mixing the composite strain powder and the mixtures with one another to obtain second mixtures; filling fermentation tanks with the mixtures and piling the mixtures until the heights of piles reach 1-2 meters; spreading and blending materials in the tanks once when the internal temperatures of the piles reach 60-70 DEG C and building piles again; repeatedly carrying out the steps by 3-5 times until the materials are black brown, starting to reduce the temperatures of the piles until the temperatures of the piles reach the normal temperature and completely fermenting the materials to obtain substrate materials suitable for slope greening. The process has the advantages that waste can be turned into wealth, the spraying and sowing operation cost can be reduced, and excellent economic benefits can be created for enterprises by a technology for manufacturing the spraying and sowing vegetation substrates.