The invention relates to an environmental-friendly organic profile control agent. The environmental-friendly organic profile control agent comprises partially hydrolyzed polyacrylamide, a crosslinking solution, a ternary metal compound particles, an accelerant, additives, modified bentonite, auxiliaries, a complexing agent, polymetal silicate and water. The invention further provides a preparation method and use of the profile control agent. According to the profile control agent provided by the invention, the most excellent performances are obtained by proper selection of the components, a unique process of the preparation method and the like, so that the profile control agent has good application prospect and industrial potential in the field of petroleum industry.