The invention provides a hydrocarbon oil hydrotreatment method. The method is characterized in that a slurry containing hydrogen, hydrocarbon oil and a catalyst with a catalytic hydrogenation effect passes through the reaction space of a tubular reactor under liquid phase hydrotreatment conditions, wherein the slurry is obtained in a mode 1 or a mode 2 or a mode 1 and mode 2 combination mode, the mode 1 is characterized by injecting hydrogen to the hydrocarbon oil through pores with the average aperture being a nanometer dimension to obtain hydrogen-containing hydrocarbon oil and mixing the hydrogen-containing hydrocarbon oil and the catalyst with a catalytic hydrogenation effect, and the mode 2 is characterized by injecting hydrogen to a mixture containing the hydrocarbon oil and the catalyst with a catalytic hydrogenation effect through pores with the average aperture being a nanometer dimension. The method has the advantages of good hydrogenation effect, no use of a diluent or cycle oil, high production efficiency, realization of long-cycle stable running of an apparatus, and suitableness for treatment of inferior raw materials.