The invention relates to the large power electric locomotive power module insulation isolation technology, and specifically refers to an anti-creepage isolation insulation device between drive boards, thus solving the large land occupation and easy mutual interference technical problems in a driving board mounting process in the prior art; the anti-creepage isolation insulation device between drive boards comprises an L-shape isolation plate made of insulation material; the L-shape isolation plate comprises a horizontal plate and a first vertical plate connected with one end of the horizontal plate; positions close to four vertex angles on the top surface of the horizontal plate are respectively and fixedly provided with a hexagonal pad rod made of insulation material and used for fixing and supporting the drive board. The L-shape and U-shape structure of the isolation plate can effectively isolate electrical interferences in the horizontal distance and vertical distance; the anti-creepage isolation insulation device can protect the drive boards, and can greatly increase creepage distance while saving space.