The invention relates to a medical fertilizer mixture for preventing corn top rot, wherein active ingredients of the medical fertilizer mixture for preventing the corn top rot comprises plant growth adjusting agents and mineral nutrition elements, wherein the plant growth adjusting agents are one or two of compound nitrate phenolate and diethylaminoethyl hexanoate, and the mineral nutrition elements are one or more of middle elements calcium, trace element copper, manganese, zinc soluble salt. The medical fertilizer mixture for preventing the corn top rot synthetically utilizes dual effects of mineral nutrition and induced resistance of the middle elements calcium, the manganese and the zinc, commonly acts with a growth-promoting type growth adjusting agent to induce basic resistance, enhances ability for resisting environmental stress, promotes diseased plants to rapidly recover normal growth, and prevents and controls the corn top rot to happen and develop.